Fwd: [MedicalConspiracies] Sci-fi food - Read what products contain Senomyx and avoid - it is not listed on the label except under artificial flavors

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Subject: [MedicalConspiracies] Sci-fi food - Read what products contain Senomyx and avoid - it is not listed on the label except under artificial flavors
To: "1 Health_and_Healing@yahoogroup" <Health_and_Healing@yahoogroups.com>, "1 MedicalConspiracies@googlegro" <MedicalConspiracies@googlegroups.com>, "1 Paranormal_Research@yahoogrou" <Paranormal_Research@yahoogroups.com>

SENOMYX, SWEETER THAN SWEET; SALTIER THAN SALT;
MORE SOUR THAN AN ABORTED FETUS

By Robert Cohen
Web Site: <http://www.notmilk.com>http://www.notmilk.com    Posted: 13 March 2009   Sugar, ahhh - - honey honey you are my candy girl and you got me wanting you I just can't believe the loveliness of loving you (I just can't believe its true) I just can believe the wonder of this feeling too (I just can't believe its true)  --Wilson Pickett, 1970 (Written by Barry and Andy Kim)   We are witnessing the dawning of a sci-fi food  revolution. A new technology. A new food group.  Amazingly, my research uncovered something nobody  has ever revealed before in a column, newspaper  article, or magazine expose. The next time you  read "artificial flavor" on a food label, you  should be aware that a component of that new  genetically engineered food additive may be  embryonic kidney cells from aborted human fetuses.  The new high-tech artificial flavors are not  flavors at all. Instead, they contain chemicals  which have been engineered to fool human taste  buds. Future foods will need no salt, sugar, MSG,  or artificial sweeteners. Instead, sensory  perceptions will become warped by modern science.  Brains will taste things that are not really  there. Illusions. Deceptions. Memories of taste  which are now artificially induced.  You may not understand the abstract of the most  recent publication from this new food science, as  published in the May 2, 2008 issue of the Journal  of Biochemistry. I will translate.  The Abstract:  @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@

J Biol Chem. 2008 May 2;283(18):11981-94.
Small molecule activator of the human epithelial sodium
channel.Lu M, Echeverri F, Kalabat D, Laita B, 
Dahan DS, Smith RD, Xu H, Staszewski L, Yamamoto 
 J, Ling J, Hwang N, Kimmich R, Li P, Patron E, Keung W, Patron A, Moyer BD.
Senomyx, Inc., San Diego, California 92121.

The epithelial sodium channel (ENaC), a 
heterotrimeric complex composed of alpha, beta, 
 and gamma subunits, belongs to the ENaC/degenerin 
family of ion channels and forms the principal 
route for apical Na(+) entry in many reabsorbing epithelia.

Although high affinity ENaC blockers, including 
 amiloride and derivatives, have been described, 
potent and specific small molecule ENaC 
activators have not been reported. Here we 
describe compound S3969 that fully and reversibly 
activates human ENaC (hENaC) in an 
 amiloride-sensitive and dose-dependent manner in 
heterologous cells. Mechanistically, S3969 
increases hENaC open probability through 
interactions requiring the extracellular domain 
of the beta subunit. hENaC activation by S3969 
 did not require cleavage by the furin protease, 
indicating that nonproteolyzed channels can be 
opened. Function of alphabetaG37Sgamma hENaC, a 
channel defective in gating that leads to the 
salt-wasting disease pseudohypoaldosteronism type 
 I, was rescued by S3969. Small molecule 
activation of hENaC may find application in 
alleviating human disease, including 
pseudohypoaldosteronism type I, hypotension, and 
neonatal respiratory distress syndrome, when 
 improved Na(+) flux across epithelial membranes is clinically desirable.

@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@

OK, so what does it all mean? Another question:

What's $6 today and $100 in the Near Future? SNMX trades on NASDAQ
 
<http://www.senomyx.com>http://www.senomyx.combioportfolio.com) will provide more info than 
 you need to know. See: United States Patent #5,993,778.

How far into the future will these new biotech 
wonders appear in our food supply? The future is 
now. The next time you read "artificial flavor" 
 on a food label, pause to consider what you've 
read here today. Content labels should read: 
Embryonic kidney cells from aborted human fetuses.

Senomyx is presently developing new products with 
many of the world's largest food manufacturers 
 including Campbell's and Coca Cola. In fact, if 
you eat Nestle's foods, your taste buds are being 
artificially stimulated by biotech products 
developed by Senomyx. You may now know what you 
are eating, but I take this opportunity to 
 paraphrase 17th century author Miguel Cervantes, who wrote in Don Quixote:

"The proof is in the pudding."

Robert Cohen
<http://www.notmilk.com>http://www.notmilk.com<http://www.flex-news-food.com/console//console/PageViewer.aspx?page=1>Food 
 Industry News

Categories: 
<http://www.flex-news-food.com/console//console/PageViewer.aspx?page=6>Corpora   From the Senomyx website: Translation: Senomyx  is re-inventing food and flavor by genetically  engineering taste bud receptor cell triggers.  Foods of the future will contain "flavor  enhancers" which fool human taste buds into  perceiving the sensations of sweetness, sourness, saltiness, and bitterness.  Remember the artificial sweetener controversies?  Chemical sugar-replicating compounds are listed  on food labels. The new chemicals made by biotech  companies will require no such labels. Although  they are not actual flavors, they will be called "artificial flavors."  How did Senomyx accomplish the task? A  (multi-hour) review of their patents reveals that  it all began with the cloning of human embryonic  kidney cells. Step two was a recombinant process  involving the combination of genetic material  from embryonic kidney cells and human  adeno-virus. If I had the ability to recall ten  thousand abbreviations for the amino acid  sequence, plus hundreds of complex combinations  of ACTG (adeneine, cytosine, thymine, guanine)  I'd describe the structure to you. For those  curious scientists, do a google search with the  keywords 'Senomyx and patents' and the third link  (     Friday, 6 August 2010, 9:41  :.  te 
Results | 
<http://www.flex-news-food.com/console//console/PageViewer.aspx?page=16087>Food 
 Ingredients News




Senomyx Q2 Revenues Up 91%; Outlook Encouraging

Source: Senomyx, Inc
05/08/2010
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August 5 - Senomyx, Inc., a company focused on 
 using proprietary taste receptor-based 
technologies to discover novel flavor ingredients 
for the food, beverage, and ingredient supply 
industries, today provided a corporate update and 
reported financial results for the second quarter ended June 30, 2010.
 
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 Revenues were $5.7 million for the second quarter 
of 2010, compared to $3.0 million for the second 
quarter of 2009, an increase of 91%. Revenues 
were $13.4 million for the six months ended June 
30, 2010, compared to $6.5 million for the six 
 months ended June 30, 2009, an increase of 107%. 
As of June 30, 2010, the Company had cash, cash 
equivalents, and short term investments of approximately $55.4 million.

 The second quarter of 2010 has been very active 
 for Senomyx,  stated Kent Snyder, Chief Executive 
Officer of the Company.  During the quarter we 
were informed that the European Food Safety 
Authority (EFSA) has provided a  favorable 
opinion  for Senomyx s Savory Flavor Ingredients, 
 S336 and S807, which means that no further 
evaluation is required. The successful conclusion 
of the evaluation is a key step toward receiving 
an approval to use these ingredients in the European Union. 

 Senomyx s Savory Flavor Ingredients are intended 
to reduce or replace added monosodium glutamate 
(MSG) in foods and beverages. Final regulatory 
approval and commercialization in the EU is 
contingent upon the ingredients being included in 
 the EFSA Union List, which EFSA has targeted for 
publication by the end of 2010.

 Nestlé, the world s largest food and beverage 
company, is currently conducting marketing 
activities in the Pacific Rim, Latin America, and 
 Africa with both new and reformulated established 
products that incorporate Senomyx s Savory Flavor 
Ingredients. Approval in Europe could create a 
new market opportunity for Nestlé,  Snyder noted.

 In addition, Ajinomoto, a leading global 
 manufacturer of food and culinary products, is 
introducing products that contain a Senomyx 
flavor ingredient in Asia and another key 
region,  Snyder stated.  Ajinomoto has increased 
the number of products launched and has also 
 selected several new Senomyx flavor ingredients 
for potential marketing.  Selection of the new 
ingredients, which are all currently being 
evaluated by Ajinomoto, triggered a $500,000 milestone payment to Senomyx.
 
 Another Senomyx partner, Firmenich, is 
continuing commercial activities for Senomyx s 
extremely effective enhancer of the 
high-intensity sweetener sucralose (S2383),  
Snyder said. Firmenich SA, a global leader in 
 providing ingredients and flavor systems to major 
consumer companies, has exclusive worldwide 
rights to market the sucralose enhancer as either 
a stand-alone ingredient or as part of a flavor 
system in all food and beverage product categories.
 
 Senomyx s recent scientific achievements include 
important progress in our Bitter Blocker Program 
during the past quarter,  Snyder noted. 
 Development activities, including primary safety 
studies, have now been completed for our S6821 
 Bitter Blocker, allowing Senomyx to submit 
regulatory filings for S6821 in the second half 
of the year. S6821 is effective in reducing the 
bitterness of a variety of product prototypes. We 
are encouraged by the accelerated pace of our 
 development activities and the potential 
long-term value of our Bitter Blocker Program.

 We are also enthusiastic about the success 
Senomyx has had with our Sweet Enhancer program,  
Snyder commented.  As announced on June 24, our 
 advances in this program have led to Senomyx and 
PepsiCo, the world s second-largest food and 
beverage company, signing a letter agreement and 
entering into an exclusive 60-day negotiation 
period regarding the completion of a definitive 
 agreement for a new collaboration related to 
Senomyx s sweet taste technology. 

Senomyx s letter agreement with PepsiCo includes 
key commercial and financial terms for a 
potential multi-year collaborative research 
 program focused on the discovery, development, 
and commercialization of new artificial sweet 
enhancers, natural sweet enhancers, and natural 
high potency sweeteners for the non-alcoholic 
beverage category. Under the letter agreement, 
 Senomyx has received a payment of $7.5 million 
from PepsiCo. The payment, which is 
non-refundable except under limited 
circumstances, will be applied as partial payment 
towards an upfront license fee if Senomyx and 
 PepsiCo enter into a final definitive agreement.

 PepsiCo is an innovative company that shares our 
commitment to providing healthier, great-tasting 
products to consumers. We believe that our 
potential new collaboration would include a 
 commercialization timeframe and other terms that 
are beneficial for both companies,  Snyder stated.

In addition to other accomplishments, the Company 
increased its intellectual property portfolio 
during the past quarter. As of June 30, 2010, 
 Senomyx is the owner or exclusive licensee of 207 
issued patents and 362 pending patent 
applications related to proprietary taste 
receptor technologies in the U.S., Europe, and 
elsewhere. Technologies covered in the Company s 
 patents include taste receptor sequences and 
functions, screening assays, new flavor ingredients, and product applications.

Senomyx achieved its recent scientific advances 
under the leadership of Donald S. Karanewsky, 
 Ph.D., who has served as Senior Vice President, 
Discovery since joining Senomyx in June 2007. In 
recognition of his valuable contributions to the 
Company, Dr. Karanewsky was appointed to the 
position of Senior Vice President and Chief 
 Scientific Officer during the past quarter. Dr. 
Karanewsky received his Ph.D. and Master s 
degrees in Chemistry from Harvard University and 
was granted a B.S. in Chemistry, Magna Cum Laude, 
from Stevens Institute of Technology in New Jersey.
 
Senomyx management will discuss the Company s 
recent events during a conference call at 11:00 
a.m. Eastern Time (8:00 a.m. Pacific Time) today. 
Details regarding access to the call and a 
subsequent archived recording are provided below.
 
Discovery & Development Program Updates:

Sweet Enhancer Program: The primary goal for this 
program is to identify flavor ingredients that 
allow a significant reduction of sweeteners in 
food and beverage products while maintaining the 
 desired sweet taste. Senomyx has received a GRAS 
(Generally Recognized As Safe) regulatory 
designation for S6973, the Company s sucrose 
enhancer that enables up to 50% reduction of 
sugar in certain foods and beverages while 
 maintaining the sweet taste of natural sugar. The 
GRAS designation allows it to be used in the U.S. 
and in numerous other countries for most food 
products and selected beverages such as flavored 
milk, as well as ready-to-drink and instant 
 coffee and tea. The sucrose enhancer is currently 
being evaluated by potential collaborators 
interested in using it for these beverage 
categories. Firmenich has exclusive worldwide 
rights to commercialize this sucrose enhancer for 
 virtually all food categories, and co-exclusive 
rights for the powdered beverage category. 
Firmenich has initiated pre-commercialization 
activities with major clients in anticipation of 
conducting its first product launches during 2011.
 
Additional advances with the Sweet Enhancer 
Program include the identification of a new 
family of sucrose enhancers with distinct 
physical properties that may be advantageous for 
a broader range of beverages and other product 
 applications. A recently discovered sucrose 
enhancer from this family enables up to 50% 
reduction of sugar in preliminary taste tests.

During the first quarter of 2010, the Company 
identified the first Senomyx flavor ingredients 
 that demonstrate a statistically significant 
amplification of the sweet taste of fructose, a 
key component of high fructose corn syrup. High 
fructose corn syrup is the primary sweetener used 
in carbonated and certain other beverages, 
 especially in North America. A number of new 
samples have been active in the fructose enhancer 
screening assay. These are being optimized to 
increase their potency and improve their physical 
properties, followed by evaluation in taste tests.
 
Bitter Blocker Program: The primary goals of this 
program are to reduce or block bitter taste and 
to improve the overall taste characteristics of 
foods, beverages, and ingredients. Taste tests 
have demonstrated that S6821 and S0812, alone or 
 in combination, can provide statistically 
significant reductions in the bitterness of a 
variety of product prototypes and food 
ingredients including tea, cocoa, menthol, 
various proteins, and the sweeteners 
 Rebaudioside-A (a derivative of the stevia 
plant), Acesulfame potassium (Ace-K), and 
saccharine. Senomyx expects to submit regulatory 
applications for S6821 during the second half of 
this year. In addition, the Company believes 
 development activities with S0812 will conclude 
by year-end and regulatory filings are planned for 2011.

Salt Enhancer Program: The goal of the Salt 
Enhancer Program is to identify flavor 
ingredients that allow a significant reduction of 
 sodium in foods and beverages yet maintain the 
salty taste desirable to consumers. Senomyx 
discovered SNMX-29, a protein with 
characteristics that indicate it could be 
involved in human salt taste perception, and 
 identified samples that are active in screening 
assays based on this protein. These active 
samples have not provided significant enhancement 
of saltiness in taste tests, which leads the 
Company to believe that SNMX-29 is not the 
 primary receptor responsible for human salt 
taste. The Company is exploring the role of other 
proteins that may be integral to the sensation of 
salty taste. This high-priority effort involves 
chemistry and biology approaches, including 
 assessing components of Senomyx s proprietary 
database of proteins found in taste buds. Senomyx 
believes that discovery of the protein or 
proteins that function as the salt taste receptor 
could lead to identifying a salt taste enhancer.
 
Cooling Flavor Program: The goal of the Cooling 
Flavor Program is to identify novel cooling 
flavors that do not have the limitations of 
currently available agents. Senomyx has 
discovered new cooling flavors that demonstrated 
 a taste proof-of-concept and displayed cooling 
properties that exceed those of commonly used 
agents. Senomyx and its partner for this program, 
Firmenich, have prioritized sample classes that 
are the focus of further optimization.
 
Financial Review:

Revenues were $5.7 million for the second quarter 
of 2010, compared to $3.0 million for the second 
quarter of 2009, an increase of 91%. Revenues 
were $13.4 million for the six months ended June 
 30, 2010, compared to $6.5 million for the six 
months ended June 30, 2009, an increase of 107%. 
The increases in revenues for the second quarter 
and the year-to-date were primarily due to the 
recognition of license fee and R&D funding 
 revenue related to the Company s August 2009 
Sweet Enhancer collaboration with Firmenich. 
License fee and R&D funding related to the 
collaboration contributed $3.3 million and $6.2 
million for the three and six month periods 
 ending June 30, 2010. Also contributing to the 
increase year-to-date was a total of $3.0 million 
in non-recurring milestone payments and cost 
reimbursements from collaborators.

Research and development expenses, including 
 stock-based compensation expense, were $7.1 
million for the second quarter of 2010, compared 
to $7.8 million for the second quarter of 2009, a 
decrease of 10%. Research and development 
expenses, including stock-based compensation 
 expense, were $13.5 million for the six months 
ended June 30, 2010, compared to $15.4 million 
for the six months ended June 30, 2009, a 
decrease of 13%. These decreases were primarily 
due to reduced expenditures for compound 
 acquisition and related high-throughput screening 
activities and reduced personnel-related expenses.

General and administrative expenses, including 
stock-based compensation expense, were $3.3 
million for the second quarter of 2010, compared 
 to $3.2 million for the second quarter of 2009, 
an increase of 3%. General and administrative 
expenses, including stock-based compensation 
expense, were $6.4 million for the six months 
ended June 30, 2010, compared to $6.5 million for 
 the six months ended June 30, 2009, a decrease of 1%.

The net loss for the second quarter of 2010 was 
$0.12 per share, compared to a net loss of $0.26 
per share for the second quarter of 2009. The net 
loss for the six months ended June 30, 2010 was 
 $0.18 per share, compared to $0.50 per share for 
the six months ended June 30, 2009.

2010 Outlook:

 Due to the receipt of $7.5 million from PepsiCo 
related to the June letter agreement, we are 
revising our cash utilization guidance for 2010 
 from a range of $14 million to $16 million to a 
range of $6 million to $8 million. At this time, 
we are not revising our other financial guidance 
metrics; however, we will update our financial 
guidance as necessary if we enter into a 
 definitive agreement with PepsiCo,  stated Tony 
Rogers, Vice President and Chief Financial Officer.

For the full year 2010, Senomyx now expects:
Total revenues of $20 million to $24 million 
Total expenses of $42 million to $44 million, of 
 which $5 million to $6 million is non-cash, 
stock-based compensation expense Net loss of $18 
million to $21 million Basic and diluted net loss 
of $0.48 to $0.56 per share Net cash used in 
operating activities between $6 million and $8 million
 

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